About Us

A clinical-stage antiviral company, working in the eye first

One molecule, four pillars

Okogen is developing ranpirnase, a host-directed ribonuclease with broad-spectrum antiviral activity, as a platform technology across four therapeutic pillars.

The company has freedom to operate and unencumbered access to develop, manufacture and market ranpirnase in the U.S. and globally. Our lead product candidate, Treyegen™ (OKG-0303), is a fixed-dose eye drop combining ranpirnase, an ocular decongestant and an antibacterial, in development for acute infectious conjunctivitis.

Ranpirnase has been dosed in more than 1,000 patients and shows significant selectivity indices against 23 viruses in independent testing.

Milestones

Early 1970s
Kuslima Shogen, PhD and Tsunao Yoon, PhD carry out the extract discovery work with Rana pipiens embryos — the biological origin of ranpirnase.

1994
First published antiviral activity: Onconase inhibited HIV-1 replication by approximately 90–99.9% in infected H9 cells.

2015
Okogen, Inc. is founded. Ranpirnase first demonstrates activity against Ebola virus in infected cells and a mouse model.

2018
Okogen’s $10M Series A closes. First in-vitro and clinical evidence against HPV, including healing of anogenital warts in a Phase I study. The RUBY study is initiated.

2021
RUBY interim analysis reports safe, dose-responsive antiviral activity, but no improvement in signs and symptoms, which sets the design of the combination.

2022
Joshua Moriarty is appointed Chief Executive Officer.

2023
A corporate reorganization and re-focused strategy accompany the initiation of the program for OKG-0303.

2024
$3.3M in financing completes and introducing the AI evaluation tool for conjunctivitis.

2025
A regulatory application for the EMERALD study is submitted to CDSCO in India, and David Hollander is appointed Chief Medical Officer.

2026
CDSCO authorizes IND clearance and the EMERALD Phase 1/2 study commences.

Meet the Team

Management

Joshua Moriarty

Joshua H. Moriarty

CEO & Director
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David A. Hollander, MD, MBA

Chief Medical Officer
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Bradford A. Conlan

EXECUTIVE CHAIRMAN
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Independent Directors

Brian M Strem, PhD

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Eric Daniels, MD, MBA

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Quinton Oswald

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Aiman

Aiman Shilad, MD, MBA

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Foltz

Joshua Foltz

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Scientific & Medical Advisory Board

Francis Mah, MD

Jay Pepose, MD, PhD

John Sheppard, MD

Stephanie Watson, MD