Pillar Three

Systemic Antivirals

One formulation platform, five respiratory indications, led by influenza A/B.

Pipeline

Candidate
Preclinical
Phase I
Phase II
Phase III
FDA Review
Marketed
Status
OKG-0101Influenza A/BIntranasal / inhaled
Preclinical
OKG-0102RSVIntranasal / inhaled
Preclinical
OKG-0103AdenovirusIntranasal / inhaled
Preclinical
OKG-0104Rhinovirus (common cold)Intranasal / inhaled
Preclinical
OKG-0105COVID-19Intranasal / inhaled
Preclinical

Overview

Five programs that share a formulation

All five programs could potentially use the same formulation and delivery, differing only by indication, with significant patent-life extension across the family. Data and formulations generated from the influenza program can serve as the basis for developing the others commercially.

Portfolio

The Programs

OKG-0101

Influenza A/B

The lead. Screening and formulation work is underway for both intranasal and inhaled forms, ahead of a clinical program in influenza A/B.

OKG-0102

RSV

Paramyxovirus, with a significant selectivity index in independent testing.

OKG-0103

Adenovirus

The same virus family the ophthalmic program has already suppressed in vivo.

OKG-0104

Rhinovirus

The common cold. A high-prevalence respiratory target with no approved antiviral therapy.

OKG-0105

COVID-19

Coronaviruses, including MERS and SARS, both show activity in independent testing.

Our Approach

Why the platform approach works

Screened across targets

Intranasal and inhaled formulations are screened across the respiratory target set rather than developed one indication at a time.

A lead with stockpile potential

The influenza program carries government stockpile potential alongside its commercial path, and is a candidate for government funding.

Data that compounds

Shared data and formulations accelerate every follow-on indication and extend effective patent life across the family.
There is precedent for government funding of a single influenza antiviral program at scale, which is the template for a respiratory antiviral franchise of this shape.